The device is designed for right handed people such that the user can simultaneously use the navigation buttons with their left hand while holding the device and use the stylus with their right hand.
From photographs of the device it appears that similar functionality can be provided for left handed users by rotating what is displayed on the screen 180 degrees and using the device 'upside-down'. That is the user holds the device in his/her free hand (right hand for left handed person) with the stylus in their writing hand (left for left handed person).
Although the placement of the navigation buttons means that the left-handed person will not be using the device exactly as if it were designed for a left-handed person (instead of a right handed person) it seems to be an excellent compromise.
